Issue 6, 2011
From the journal:

RSC Advances

Synthesis of 2-alkyl substituted benzimidazoles under microwave irradiation: Anti-proliferative effect of some representative compounds on human histiocytic lymphoma cellU937†

Chhanda Mukhopadhyay,*a   Sabari Ghosh,a   Sumita Sengupta (Bandyopadhyay)b  and  Soumasree Deb  

* Corresponding authors

a Department of Chemistry, University of Calcutta, 92 APC Road, Kolkata, India
E-mail: cmukhop@yahoo.co.in
Tel: +91 9433019610

b Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, 92 APC Road, Kolkata, India

Abstract

The objective of this research was the synthesis of 2-alkyl substituted benzimidazoles under microwave irradiation using 62% aqueous hexafluorophosphoric acid (10 mol%) as catalyst. Some of the newly synthesised compounds were tested for their potential to inhibit proliferation of cancer cells (histiocytic lymphoma cell U937) by cell viability assay.

Graphical abstract: Synthesis of 2-alkyl substituted benzimidazoles under microwave irradiation: Anti-proliferative effect of some representative compounds on human histiocytic lymphoma cell U937

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Article information

DOI
https://doi.org/10.1039/C1RA00470K
Article type
Paper
Submitted
16 Jul 2011
Accepted
30 Jul 2011
First published
07 Sep 2011

RSC Adv., 2011,1, 1033-1037

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Synthesis of 2-alkyl substituted benzimidazoles under microwave irradiation: Anti-proliferative effect of some representative compounds on human histiocytic lymphoma cell U937

C. Mukhopadhyay, S. Ghosh, S. Sengupta (Bandyopadhyay) and S. De, RSC Adv., 2011, 1, 1033 DOI: 10.1039/C1RA00470K

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