Issue 12, 2011
From the journal:

Chemical Science

Use of precatalysts greatly facilitate palladium-catalyzed alkynylations in batch and continuous-flow conditions†

Wei Shua  and  Stephen L. Buchwald*a  

* Corresponding authors

a Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA
E-mail: sbuchwal@mit.edu
Fax: (+1) 617-253-3297

Abstract

A general and efficient condition for palladium-catalyzed Heck alkynylation in batch was developed using a novel precatalyst. In addition, the first general and efficient continuous-flow protocol for the coupling of alkynes with aryl bromides in the absence of copper was reported.

Graphical abstract: Use of precatalysts greatly facilitate palladium-catalyzed alkynylations in batch and continuous-flow conditions

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Article information

DOI
https://doi.org/10.1039/C1SC00409C
Article type
Edge Article
Submitted
28 Jun 2011
Accepted
22 Aug 2011
First published
07 Sep 2011

Chem. Sci., 2011,2, 2321-2325

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Use of precatalysts greatly facilitate palladium-catalyzed alkynylations in batch and continuous-flow conditions

W. Shu and S. L. Buchwald, Chem. Sci., 2011, 2, 2321 DOI: 10.1039/C1SC00409C

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