Issue 1, 2012
From the journal:

Analyst

DNAzyme-based fluorescent microarray for highly selective and sensitive detection of lead(ii)†

Meiying Liu,‡ac   Xinhui Lou,‡*b   Juan Du,ac   Ming Guan,b   Jing Wang,b   Xiaofan Dingb  and  Jianlong Zhao*a  

* Corresponding authors

a State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Changning Rd. 865, Shanghai, China
E-mail: jlzhao@mail.sim.ac.cn

b Department of Chemistry, Capital Normal University, Xisanhuan North Rd. 105, Beijing, China
E-mail: xlou9999@yahoo.com
Fax: +86 10 68902320
Tel: +86 10 68902491 ext 808

c Graduate School of the Chinese Academy of Sciences, Beijing, China

Abstract

A facile microarray-based fluorescent sensor for the detection of lead (II) was developed based on the catalytic cleavages of the substrates by a DNAzyme upon its binding to Pb2+. The release of the fluorophore labelled substrates resulted in the decrease of fluorescence intensity. The sensor had a quantifiable detection range from 1 nM to 1 μM and a selectivity of >20 fold for Pb2+ over other metal ions.

Graphical abstract: DNAzyme-based fluorescent microarray for highly selective and sensitive detection of lead(ii)

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Article information

DOI
https://doi.org/10.1039/C1AN15633K
Article type
Communication
Submitted
22 Jul 2011
Accepted
04 Oct 2011
First published
28 Oct 2011

Analyst, 2012,137, 70-72

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DNAzyme-based fluorescent microarray for highly selective and sensitive detection of lead(II)

M. Liu, X. Lou, J. Du, M. Guan, J. Wang, X. Ding and J. Zhao, Analyst, 2012, 137, 70 DOI: 10.1039/C1AN15633K

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