Issue 13, 2012
From the journal:

Analyst

Highly sensitive DNA hybridization detection with single nanoparticle flash-lamp darkfield microscopy†‡

Zhiqin Yuan,§a   Jing Cheng,§a   Xiaodong Cheng,a   Yan He*a  and  Edward S. Yeunga  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, P. R. China
E-mail: yanhe2021@gmail.com
Fax: +86-731-88823074
Tel: +86-731-88821904

Abstract

We developed a novel method for counting single gold nanoparticles in free solution with flash-lamp darkfield microscopy and demonstrated that it could be applied to highly sensitive DNA hybridization detection based on target DNA induced AuNP aggregation and counts reduction.

Graphical abstract: Highly sensitive DNA hybridization detection with single nanoparticle flash-lamp darkfield microscopy

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Article information

DOI
https://doi.org/10.1039/C2AN16171K
Article type
Communication
Submitted
29 Nov 2011
Accepted
01 Feb 2012
First published
22 Feb 2012

Analyst, 2012,137, 2930-2932

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Highly sensitive DNA hybridization detection with single nanoparticle flash-lamp darkfield microscopy

Z. Yuan, J. Cheng, X. Cheng, Y. He and E. S. Yeung, Analyst, 2012, 137, 2930 DOI: 10.1039/C2AN16171K

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