Issue 13, 2012
From the journal:

Analyst

Transmission Raman spectroscopy for quality control in model cocrystal tablets†

Jonathan C. Burley,*a   Aalae Alkhalil,a   Matthew Bloomfieldb  and  Pavel Matousekbc  

* Corresponding authors

a School of Pharmacy, Boots Science Building, University of Nottingham, Nottingham, UK
E-mail: jonathan.burley@nottingham.ac.uk
Tel: +44 (0)115 8468357

b Cobalt Light Systems, The Electron Building, Harwell, Oxford, UK

c Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell, Oxford, UK

Abstract

Transmission Raman spectroscopy is employed for the first time to analyse model formulations comprising tabletted cocrystals. The ability of transmission Raman to differentiate between formulations on the basis of both drug loading and drug chemistry (cocrystal versus separate components) is investigated.

Graphical abstract: Transmission Raman spectroscopy for quality control in model cocrystal tablets

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Article information

DOI
https://doi.org/10.1039/C2AN35216H
Article type
Paper
Submitted
15 Feb 2012
Accepted
26 Apr 2012
First published
03 May 2012

Analyst, 2012,137, 3052-3057

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Transmission Raman spectroscopy for quality control in model cocrystal tablets

J. C. Burley, A. Alkhalil, M. Bloomfield and P. Matousek, Analyst, 2012, 137, 3052 DOI: 10.1039/C2AN35216H

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