Issue 10, 2012
From the journal:

Chemical Communications

Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation†‡

Maragani Satyanarayana,a   Francesca Vitali,a   John R. Frosta  and  Rudi Fasan*a  

* Corresponding authors

a Department of Chemistry, University of Rochester, Rochester NY, USA
E-mail: fasan@chem.rochester.edu
Fax: +1 585-276-0205
Tel: +1 585-275-3504

Abstract

Macrocyclic Organo-Peptide Hybrids (MOrPHs) can be prepared from genetically encoded polypeptidesvia a chemoselective and catalyst-free reaction between a trifunctional oxyamino/amino-thiol synthetic precursor and an intein-fusion protein incorporating a bioorthogonal keto group.

Graphical abstract: Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

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Article information

DOI
https://doi.org/10.1039/C1CC13533C
Article type
Communication
Submitted
15 Jun 2011
Accepted
11 Aug 2011
First published
07 Sep 2011

Chem. Commun., 2012,48, 1461-1463

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Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

M. Satyanarayana, F. Vitali, J. R. Frost and R. Fasan, Chem. Commun., 2012, 48, 1461 DOI: 10.1039/C1CC13533C

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