Issue 1, 2012
From the journal:

Chemical Communications

A facile approach for the delivery of inorganic nanoparticles into the brain by passing through the blood–brain barrier (BBB)†

Yeong Shin Yim,a   Jin-sil Choi,b   Gun Tae Kim,a   Chul Hoon Kim,a   Tae-Hyun Shin,b   Dong Goo Kim*a  and  Jinwoo Cheon*b  

* Corresponding authors

a Department of Pharmacology, Yonsei University, College of Medicine, Seoul 120-752, Korea
E-mail: dgkimpharm@yuhs.ac

b Department of Chemistry, Yonsei University, Seoul 120-749, Korea
E-mail: jcheon@yonsei.ac.kr

Abstract

This study provides an easy and simple method to obtain inorganic nanoparticles that can penetrate the blood–brain barrier, the heavily guarded system in the brain, via cross-linked serum albumin surface coatings. Their intact BBB permeability was confirmed in both in vitro and in vivo tests.

Graphical abstract: A facile approach for the delivery of inorganic nanoparticles into the brain by passing through the blood–brain barrier (BBB)

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Article information

DOI
https://doi.org/10.1039/C1CC15113D
Article type
Communication
Submitted
17 Aug 2011
Accepted
19 Oct 2011
First published
07 Nov 2011

Chem. Commun., 2012,48, 61-63

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A facile approach for the delivery of inorganic nanoparticles into the brain by passing through the blood–brain barrier (BBB)

Y. S. Yim, J. Choi, G. T. Kim, C. H. Kim, T. Shin, D. G. Kim and J. Cheon, Chem. Commun., 2012, 48, 61 DOI: 10.1039/C1CC15113D

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