Issue 4, 2012
From the journal:

Chemical Communications

Synthesis of chromans viaPd-catalyzed alkene carboetherification reactions†‡

Amanda F. Ward,a   Yan Xua  and  John P. Wolfe*a  

* Corresponding authors

a University of Michigan, Department of Chemistry, 930 N. University Ave., Ann Arbor, MI, USA
E-mail: jpwolfe@umich.edu
Tel: +1 734-763-3432

Abstract

A new method for the construction of 2-substituted and 2,2-disubstituted chromans viaPd-catalyzed carboetherification reactions between aryl/alkenyl halides and 2-(but-3-en-1-yl)phenols is described. These reactions effect formation of a C–O bond and a C–C bond to afford the chroman products in good yield, and also provide stereoselective access to tricyclic chroman derivatives.

Graphical abstract: Synthesis of chromans viaPd-catalyzed alkene carboetherification reactions

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Article information

DOI
https://doi.org/10.1039/C1CC15880E
Article type
Communication
Submitted
22 Sep 2011
Accepted
11 Nov 2011
First published
24 Nov 2011

Chem. Commun., 2012,48, 609-611

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Synthesis of chromans viaPd-catalyzed alkene carboetherification reactions

A. F. Ward, Y. Xu and J. P. Wolfe, Chem. Commun., 2012, 48, 609 DOI: 10.1039/C1CC15880E

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