Issue 7, 2012
From the journal:

Chemical Communications

Silica encapsulated SERS nanoprobe conjugated to the bacteriophage tailspike protein for targeted detection ofSalmonella†

Li-Lin Tay,*a   Ping-Ji Huang,b   Jamshid Tanha,a   Shannon Ryan,a   Xiaohua Wu,a   John Hulsea  and  Lai-Kwan Chau*b  

* Corresponding authors

a National Research Council Canada, Ottawa, Canada
E-mail: lilin.tay@nrc-cnrc.gc.ca
Tel: +1-613-993-3919

b Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, Taiwan
E-mail: chelkc@ccu.edu.tw
Tel: +886-5272-0411 X66411

Abstract

Silica-encapsulated Raman-reporter embedded SERS nanoprobes, named nanoaggregate embedded beads (NAEBs), were conjugated to the Salmonella specific tailspike protein (TSP) isolated from the P22 bacteriophage to enable a highly specific and ultrasensitive optical transduction platform. We demonstrate three successful surface conjugation strategies and highlight the detection of a single bacterium using SERS.

Graphical abstract: Silica encapsulated SERS nanoprobe conjugated to the bacteriophage tailspike protein for targeted detection ofSalmonella

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Article information

DOI
https://doi.org/10.1039/C1CC16325F
Article type
Communication
Submitted
11 Oct 2011
Accepted
14 Nov 2011
First published
08 Dec 2011

Chem. Commun., 2012,48, 1024-1026

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Silica encapsulated SERS nanoprobe conjugated to the bacteriophage tailspike protein for targeted detection ofSalmonella

L. Tay, P. Huang, J. Tanha, S. Ryan, X. Wu, J. Hulse and L. Chau, Chem. Commun., 2012, 48, 1024 DOI: 10.1039/C1CC16325F

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