Issue 26, 2012
From the journal:

Chemical Communications

The dynamic chromatographic behavior of tri-o-thymotide on HPLC chiral stationary phases†‡

Stefano Levi Mortera,a   Rocchina Sabia,a   Marco Pierini,a   Francesco Gasparrinia  and  Claudio Villani*a  

* Corresponding authors

a Sapienza Università di Roma, Dipartimento di Chimica e Tecnologie del Farmaco, P.le A. Moro 5, Rome, Italy
E-mail: claudio.villani@uniroma1.it
Fax: +39 06 49912780
Tel: +39 06 49912777

Abstract

The interconverting stereoisomers of tri-o-thymotide have been separated by HPLC on chiral stationary phases and the temperature dependence of the dynamic chromatographic patterns has been interpreted in terms of exchange between enantiomeric propeller and helical conformations. Computed low energy structures and CD spectra were used in absolute configuration assignment.

Graphical abstract: The dynamic chromatographic behavior of tri-o-thymotide on HPLC chiral stationary phases

  • This article is part of the themed collection: Chirality
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Article information

DOI
https://doi.org/10.1039/C2CC00021K
Article type
Communication
Submitted
02 Jan 2012
Accepted
04 Feb 2012
First published
06 Feb 2012

Chem. Commun., 2012,48, 3167-3169

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The dynamic chromatographic behavior of tri-o-thymotide on HPLC chiral stationary phases

S. Levi Mortera, R. Sabia, M. Pierini, F. Gasparrini and C. Villani, Chem. Commun., 2012, 48, 3167 DOI: 10.1039/C2CC00021K

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