Issue 31, 2012
From the journal:

Chemical Communications

NHC-catalysed diastereoselective synthesis of multifunctionalised piperidinesvia cascade reaction of enals with azalactones†

Atul K. Singh,a   Ruchi Chawla,a   Ankita Raia  and  Lal Dhar S. Yadav*a  

* Corresponding authors

a Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, India
E-mail: ldsyadav@hotmail.com
Fax: +91 5322460533
Tel: +91 5322500652

Abstract

NHC-catalysed azalactone ring-opening and piperidine ring-closing cascade with α,β-unsaturated aldehydes (enals) in a one-pot operation is reported. The present reaction cascade offers a convenient method for a highly diastereoselective synthesis of multifunctionalised piperidines in excellent yields under mild conditions.

Graphical abstract: NHC-catalysed diastereoselective synthesis of multifunctionalised piperidines via cascade reaction of enals with azalactones

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Article information

DOI
https://doi.org/10.1039/C2CC00069E
Article type
Communication
Submitted
04 Jan 2012
Accepted
20 Feb 2012
First published
21 Feb 2012

Chem. Commun., 2012,48, 3766-3768

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NHC-catalysed diastereoselective synthesis of multifunctionalised piperidines via cascade reaction of enals with azalactones

A. K. Singh, R. Chawla, A. Rai and L. D. S. Yadav, Chem. Commun., 2012, 48, 3766 DOI: 10.1039/C2CC00069E

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