Issue 18, 2012
From the journal:

Chemical Communications

Early detection of insulin fibrillation: a fluorescence lifetime assay to probe the pre-fibrillar regime†

Jyotirmayee Mohanty,*a   Sharmistha Dutta Choudhury,a   Haridas Pala  and  Achikanath C. Bhasikuttan*a  

* Corresponding authors

a Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
E-mail: jyotim@barc.gov.in, bkac@barc.gov.in
Fax: +91-22-25505151

Abstract

Using human insulin, we report for the first time, the evaluation of fluorescence lifetime of an extrinsically added fluorogenic dye, Thioflavin T (ThT), as a more sensitive and convenient method for the assessment of fibrillation in the pre-fibrillar regime.

Graphical abstract: Early detection of insulin fibrillation: a fluorescence lifetime assay to probe the pre-fibrillar regime

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Article information

DOI
https://doi.org/10.1039/C2CC16974F
Article type
Communication
Submitted
10 Nov 2011
Accepted
29 Dec 2011
First published
05 Jan 2012

Chem. Commun., 2012,48, 2403-2405

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Early detection of insulin fibrillation: a fluorescence lifetime assay to probe the pre-fibrillar regime

J. Mohanty, S. Dutta Choudhury, H. Pal and A. C. Bhasikuttan, Chem. Commun., 2012, 48, 2403 DOI: 10.1039/C2CC16974F

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