Issue 25, 2012
From the journal:

Chemical Communications

Catalytic metallodrugs targeting HCVIRESRNA†

Seth Bradforda  and  J. A. Cowan*ab  

* Corresponding authors

a Department of Chemistry, The Ohio State University, 100 W, 18th Ave, Columbus, USA
E-mail: cowan@chemistry.ohio-state.edu

b MetalloPharm LLC, 1790 Riverstone Drive, Delaware, USA

Abstract

A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with KM of 0.85 μM, kcat of 0.53 min−1, and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC50) of 0.58 μM in an HCV cellular replicon assay.

Graphical abstract: Catalytic metallodrugs targeting HCV IRES RNA

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Article information

DOI
https://doi.org/10.1039/C2CC17377H
Article type
Communication
Submitted
25 Nov 2011
Accepted
12 Jan 2012
First published
16 Jan 2012

Chem. Commun., 2012,48, 3118-3120

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Catalytic metallodrugs targeting HCV IRES RNA

S. Bradford and J. A. Cowan, Chem. Commun., 2012, 48, 3118 DOI: 10.1039/C2CC17377H

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