Issue 36, 2012
From the journal:

Chemical Communications

Inter-chain acyl transfer reaction in a peptide six-helical bundle: a chemical method for regulating the interaction between peptides or proteins†

Yu Bai,a   Huifang Xue,ab   Yanbo Ling,a   Maosheng Cheng,b   Lifeng Caia  and  Keliang Liu*a  

* Corresponding authors

a Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Haidian District, Beijing 100850, China
E-mail: keliangliu55@126.com, keliangliu@yahoo.com
Fax: +86-10-68211665

b Key Laboratory of Structure Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China

Abstract

An inter-helical acyl transfer specifically occurred between the C-and N-peptides of HIV gp41 after assembly of the six-helical bundle (6HB), forming an inter-helical covalent bond that greatly enhanced 6HB stability. In the reaction, the C-peptide was modified as an acyl donor, and the N-peptide served as an acyl acceptor.

Graphical abstract: Inter-chain acyl transfer reaction in a peptide six-helical bundle: a chemical method for regulating the interaction between peptides or proteins

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Article information

DOI
https://doi.org/10.1039/C2CC17428F
Article type
Communication
Submitted
28 Nov 2011
Accepted
08 Mar 2012
First published
08 Mar 2012

Chem. Commun., 2012,48, 4320-4322

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Inter-chain acyl transfer reaction in a peptide six-helical bundle: a chemical method for regulating the interaction between peptides or proteins

Y. Bai, H. Xue, Y. Ling, M. Cheng, L. Cai and K. Liu, Chem. Commun., 2012, 48, 4320 DOI: 10.1039/C2CC17428F

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