Issue 21, 2012
From the journal:

Chemical Communications

Coercing bisphosphonates to kill cancer cells with nanoscale coordination polymers†

Demin Liu,a   Stephanie A. Kramer,a   Rachel C. Huxford-Phillips,a   Shunzhi Wang,a   Joseph Della Roccaa  and  Wenbin Lin*a  

* Corresponding authors

a Department of Chemistry, CB#3290, University of North Carolina, Chapel Hill, North Carolina 27599, USA
E-mail: wlin@unc.edu

Abstract

Nanoscale coordination polymers containing exceptionally high loadings of bisphosphonates were coated with single lipid bilayers to control the drug release kinetics and functionalized with a targeting ligand to endow cell-targeting capability, leading to much enhanced cytotoxicity against human lung and pancreatic cancer cells.

Graphical abstract: Coercing bisphosphonates to kill cancer cells with nanoscale coordination polymers

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Article information

DOI
https://doi.org/10.1039/C2CC17635A
Article type
Communication
Submitted
06 Dec 2011
Accepted
21 Jan 2012
First published
23 Jan 2012

Chem. Commun., 2012,48, 2668-2670

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Coercing bisphosphonates to kill cancer cells with nanoscale coordination polymers

D. Liu, S. A. Kramer, R. C. Huxford-Phillips, S. Wang, J. Della Rocca and W. Lin, Chem. Commun., 2012, 48, 2668 DOI: 10.1039/C2CC17635A

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