Issue 16, 2012
From the journal:

Chemical Communications

Comparative proteomic profiling of mammalian cell lysates using phosphopeptide microarrays†

Liqian Gao,ab   Mahesh Uttamchandani*acd  and  Shao Q. Yao*ab  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore

b NUS MedChem Program of the Office of Life Sciences, National University of Singapore, 3 Science Drive 3, Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: +65 67791691
Tel: +65 65162925

c Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore

d Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, Singapore
E-mail: mahesh@dso.org.sg
Fax: +65 64857033
Tel: +65 64857214

Abstract

A library of 176 human phosphotyrosine-containing peptides was used to establish cell lysate binding profiles in a two colour microarray format. The resulting hits led to the pull-down and identification of biomarkers associated with cancer states.

Graphical abstract: Comparative proteomic profiling of mammalian cell lysates using phosphopeptide microarrays

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Article information

DOI
https://doi.org/10.1039/C2CC17701C
Article type
Communication
Submitted
08 Dec 2011
Accepted
04 Jan 2012
First published
06 Jan 2012

Chem. Commun., 2012,48, 2240-2242

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Comparative proteomic profiling of mammalian cell lysates using phosphopeptide microarrays

L. Gao, M. Uttamchandani and S. Q. Yao, Chem. Commun., 2012, 48, 2240 DOI: 10.1039/C2CC17701C

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