Issue 18, 2012
From the journal:

Chemical Communications

Mn loaded apoferritin as an MRI sensor of melanin formation in melanoma cells†

Ibolya Szabó,a   Simonetta Geninatti Crich,a   Diego Alberti,a   Ferenc K. Kálmánab  and  Silvio Aime*a  

* Corresponding authors

a Center for Molecular Imaging, Department of Chemistry IFM, University of Torino, via Nizza 52, Torino, Italy
E-mail: silvio.aime@unito.it
Fax: 0039 0116706487
Tel: 0039 0116706451

b Department of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen, Hungary

Abstract

Mn(III)-loaded apoferritin is promptly reduced to Mn(II)–apoferritin by the oxidation of L-DOPA to melanin. The process is nicely witnessed by a marked relaxation enhancement of water proton relaxation rate that has been detected both in cultured melanoma cells and in tumor animal models.

Graphical abstract: Mn loaded apoferritin as an MRI sensor of melanin formation in melanoma cells

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Article information

DOI
https://doi.org/10.1039/C2CC17801J
Article type
Communication
Submitted
13 Dec 2011
Accepted
11 Jan 2012
First published
12 Jan 2012

Chem. Commun., 2012,48, 2436-2438

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Mn loaded apoferritin as an MRI sensor of melanin formation in melanoma cells

I. Szabó, S. G. Crich, D. Alberti, F. K. Kálmán and S. Aime, Chem. Commun., 2012, 48, 2436 DOI: 10.1039/C2CC17801J

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