Issue 28, 2012
From the journal:

Chemical Communications

The first total synthesis of (+)-mucosin†‡

Alan R. Henderson,a   Jozef Stec,a   David R. Owena  and  Richard J. Whitby*a  

* Corresponding authors

a Chemistry, University of Southampton, Southampton, Hampshire, UK
E-mail: R.J.Whitby@soton.ac.uk
Fax: +44 238059 3781
Tel: +44 238059 2777

Abstract

The first total synthesis of (+)-mucosin has been completed allowing assignment of the absolute stereochemistry of the natural product. A zirconium induced co-cyclisation was utilised to install the correct stereochemistry of the four contiguous stereocentres around the unusual bicyclo[4.3.0]nonene core.

Graphical abstract: The first total synthesis of (+)-mucosin

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Article information

DOI
https://doi.org/10.1039/C2CC17915F
Article type
Communication
Submitted
19 Dec 2011
Accepted
10 Feb 2012
First published
10 Feb 2012

Chem. Commun., 2012,48, 3409-3411

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The first total synthesis of (+)-mucosin

A. R. Henderson, J. Stec, D. R. Owen and R. J. Whitby, Chem. Commun., 2012, 48, 3409 DOI: 10.1039/C2CC17915F

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