Issue 41, 2012

Isonicotinamide self-association: the link between solvent and polymorph nucleation

Abstract

We show that, in a controlled and reproducible way, specific solvents lead to specific polymorphic forms of isonicotinamide. We argue on the basis of Raman and FTIR spectroscopy that the hydrogen bonding in solution kinetically drives the nucleation towards a specific form. This generally may lead to good understanding and control of polymorphism and crystal nucleation.

Graphical abstract: Isonicotinamide self-association: the link between solvent and polymorph nucleation

Supplementary files

Article information

Article type
Communication
Submitted
22 Dec 2011
Accepted
22 Mar 2012
First published
23 Mar 2012

Chem. Commun., 2012,48, 4983-4985

Isonicotinamide self-association: the link between solvent and polymorph nucleation

S. A. Kulkarni, E. S. McGarrity, H. Meekes and J. H. ter Horst, Chem. Commun., 2012, 48, 4983 DOI: 10.1039/C2CC18025A

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