Issue 34, 2012

Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines

Abstract

Enantioselective synthesis of β-trifluoromethylated pyrrolines has been developed by the organocatalyzed-conjugated addition of nitromethane to β-trifluoromethylated enones, followed by a nitro-reduction/cyclization/dehydration sequence in a one-pot procedure with 97–98% ees.

Graphical abstract: Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines

Supplementary files

Article information

Article type
Communication
Submitted
23 Dec 2011
Accepted
09 Feb 2012
First published
10 Feb 2012

Chem. Commun., 2012,48, 4067-4069

Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines

H. Kawai, T. Kitayama, E. Tokunaga, T. Matsumoto, H. Sato, M. Shiro and N. Shibata, Chem. Commun., 2012, 48, 4067 DOI: 10.1039/C2CC18049A

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