Issue 23, 2012
From the journal:

Chemical Communications

Synthesis and evaluation of triazole-linked poly(ε-caprolactone)-graft-poly(2-methyl-2-oxazoline) copolymers as potential drug carriers†

Brieuc Guillerm,a   Vincent Darcos,b   Vincent Lapinte,a   Sophie Monge,*a   Jean Coudaneb  and  Jean-Jacques Robina  

* Corresponding authors

a Institut Charles Gerhardt Montpellier UMR5253 CNRS-UM2-ENSCM-UM1 - Equipe Ingénierie et Architectures Macromoléculaires, Université Montpellier II cc1702, Place Eugène Bataillon, 34095 Montpellier, France
E-mail: sophie.monge-darcos@univ-montp2.fr
Fax: +33-467144028
Tel: +33-467144158

b Max Mousseron Institute of Biomolecules, UMR5247 CNRS, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15, avenue Charles Flahault, BP 14491, 34093 Montpellier, France

Abstract

Well-defined graft copolymers were obtained using a copper-catalysed azide–alkyne Huisgen's cycloaddition click reaction from both biocompatible and non-toxic poly(ε-caprolactone) and poly(2-methyl-2-oxazoline) homopolymers. Resulting amphiphilic copolymers proved to form micelles that could be used as potential drug carriers.

Graphical abstract: Synthesis and evaluation of triazole-linked poly(ε-caprolactone)-graft-poly(2-methyl-2-oxazoline) copolymers as potential drug carriers

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Article information

DOI
https://doi.org/10.1039/C2CC30191A
Article type
Communication
Submitted
10 Jan 2012
Accepted
18 Jan 2012
First published
23 Jan 2012

Chem. Commun., 2012,48, 2879-2881

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Synthesis and evaluation of triazole-linked poly(ε-caprolactone)-graft-poly(2-methyl-2-oxazoline) copolymers as potential drug carriers

B. Guillerm, V. Darcos, V. Lapinte, S. Monge, J. Coudane and J. Robin, Chem. Commun., 2012, 48, 2879 DOI: 10.1039/C2CC30191A

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