Issue 25, 2012
From the journal:

Chemical Communications

Enzyme-free signal amplification in the DNAzyme sensor via target-catalyzed hairpin assembly†

Ai-Xian Zheng,a   Juan Li,a   Jin-Ru Wang,a   Xiao-Rong Song,a   Guo-Nan Chen*a  and  Huang-Hao Yang*a  

* Corresponding authors

a The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, P. R. China
E-mail: hhyang@fio.org.cn
Fax: +86 591 22866227
Tel: +86 591 22866135

Abstract

A simple, highly sensitive and enzyme-free DNAzyme sensor based on target-catalyzed hairpin assembly is developed, which permits detection of 0.1 pM target DNA. Furthermore, this DNAzyme sensor is capable of detecting target DNA in real samples because of its high selectivity.

Graphical abstract: Enzyme-free signal amplification in the DNAzyme sensor via target-catalyzed hairpin assembly

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC30305A
Article type
Communication
Submitted
14 Jan 2012
Accepted
07 Feb 2012
First published
09 Feb 2012

Chem. Commun., 2012,48, 3112-3114

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Enzyme-free signal amplification in the DNAzyme sensor via target-catalyzed hairpin assembly

A. Zheng, J. Li, J. Wang, X. Song, G. Chen and H. Yang, Chem. Commun., 2012, 48, 3112 DOI: 10.1039/C2CC30305A

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