Issue 30, 2012
From the journal:

Chemical Communications

Efficient dynamic kinetic resolution of racemic secondary alcohols by a chemoenzymatic system using bifunctional iridium complexes with C–N chelate amido ligands†‡

Yasuhiro Sato,a   Yoshihito Kayakia  and  Takao Ikariya*a  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, O-okayama 2-12-1-E4-1, Meguro-ku, Tokyo 152-8552, Japan
E-mail: tikariya@apc.titech.ac.jp, +81 3 5734 2637

Abstract

The combined catalyst system of bifunctional amidoiridium complexes derived from benzylic amines with CALB was found to provide a range of chiral acetates from racemic secondary alcohols in excellent yields with nearly perfect enantioselectivities via dynamic kinetic resolution.

Graphical abstract: Efficient dynamic kinetic resolution of racemic secondary alcohols by a chemoenzymatic system using bifunctional iridium complexes with C–N chelate amido ligands

  • This article is part of the themed collection: Chirality
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Article information

DOI
https://doi.org/10.1039/C2CC30333G
Article type
Communication
Submitted
15 Jan 2012
Accepted
15 Feb 2012
First published
17 Feb 2012

Chem. Commun., 2012,48, 3635-3637

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Efficient dynamic kinetic resolution of racemic secondary alcohols by a chemoenzymatic system using bifunctional iridium complexes with C–N chelate amido ligands

Y. Sato, Y. Kayaki and T. Ikariya, Chem. Commun., 2012, 48, 3635 DOI: 10.1039/C2CC30333G

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