Issue 32, 2012
From the journal:

Chemical Communications

A genetically encoded copper(i) sensor based on engineered structural distortion of EGFP†

Junyi Liang,a   Meng Qin,a   Rui Xu,b   Xiang Gao,a   Yan Shen,b   Qiang Xu,b   Yi Cao*a  and  Wei Wang*a  

* Corresponding authors

a National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu, China
E-mail: caoyi@nju.edu.cn, wangwei@nju.edu.cn
Fax: +86 83595535
Tel: +86 83688960

b State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu, China

Abstract

We report a genetically encoded fluorescent sensor for in vivo copper(I) imaging based on engineered intramolecular mechanical strain and structural distortion of EGFP.

Graphical abstract: A genetically encoded copper(i) sensor based on engineered structural distortion of EGFP

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Article information

DOI
https://doi.org/10.1039/C2CC30531C
Article type
Communication
Submitted
24 Jan 2012
Accepted
23 Feb 2012
First published
24 Feb 2012

Chem. Commun., 2012,48, 3890-3892

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A genetically encoded copper(I) sensor based on engineered structural distortion of EGFP

J. Liang, M. Qin, R. Xu, X. Gao, Y. Shen, Q. Xu, Y. Cao and W. Wang, Chem. Commun., 2012, 48, 3890 DOI: 10.1039/C2CC30531C

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