Issue 36, 2012
From the journal:

Chemical Communications

Tandem-type Pd(ii)-catalyzed oxidative Heck reaction/intramolecular C–H amidation sequence: a novel route to 4-aryl-2-quinolinones†

Kiyofumi Inamoto,*a   Junpei Kawasaki,a   Kou Hiroya,a   Yoshinori Kondoa  and  Takayuki Doi*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
E-mail: inamoto@m.tohoku.ac.jp, doi_taka@mail.pharm.tohoku.ac.jp
Fax: +81-22-795-5917
Tel: +81-22-795-3906

Abstract

A novel catalytic method for synthesizing 4-aryl-2-quinolinones is reported. The process involves two mechanistically independent, sequential Pd(II)-catalyzed reactions—the oxidative Heck reaction and the intramolecular C–H amidation—both of which smoothly proceed in the presence of a single catalytic system in a one-pot manner.

Graphical abstract: Tandem-type Pd(ii)-catalyzed oxidative Heck reaction/intramolecular C–H amidation sequence: a novel route to 4-aryl-2-quinolinones

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Article information

DOI
https://doi.org/10.1039/C2CC30600J
Article type
Communication
Submitted
27 Jan 2012
Accepted
07 Mar 2012
First published
08 Mar 2012

Chem. Commun., 2012,48, 4332-4334

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Tandem-type Pd(II)-catalyzed oxidative Heck reaction/intramolecular C–H amidation sequence: a novel route to 4-aryl-2-quinolinones

K. Inamoto, J. Kawasaki, K. Hiroya, Y. Kondo and T. Doi, Chem. Commun., 2012, 48, 4332 DOI: 10.1039/C2CC30600J

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