Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing

Sabah Abada; Alexandre Lecointre; Mourad Elhabiri; David Esteban-Gómez; Carlos Platas-Iglesias; Gaylord Tallec; Marinella Mazzanti; Loïc J. Charbonnière

doi:10.1039/C2CC30757J

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Highly relaxing gadolinium based MRI contrast agents responsive to Mg²⁺ sensing†

Sabah Abada,^a Alexandre Lecointre,^a Mourad Elhabiri,^b David Esteban-Gómez,^c Carlos Platas-Iglesias,^c Gaylord Tallec,^d Marinella Mazzanti^d and Loïc J. Charbonnière*^a

Author affiliations

* Corresponding authors

^a Laboratoire d'Ingénierie Moléculaire Appliquée à l'Analyse, IPHC, UMR 7178 CNRS/UdS, ECPM 25 rue Becquerel, 67087 Strasbourg Cedex 2, France
E-mail: l.charbonn@unistra.fr

^b Laboratoire de Chimie Bioorganique et Médicinale, UMR 7509 CNRS-UdS, ECPM, Université de Strasbourg, 25 rue Becquerel, 67200 Strasbourg, France

^c Departamento de Química Fundamental, Universidade da Coruña, Campus da Zapateira-Rúa da Fraga 10, 15008 A Coruña, Spain

^d Laboratoire de Reconnaissance Ionique et Chimie de Coordination, INAC, CEA Genoble, UMR-E 3 CEA-UJF, 38054 Grenoble Cedex 9, France

Abstract

A Gd complex based on a polyphosphonated pyridyl ligand shows a very high stability in aqueous solution (log K_EuL = 25.7), a high relaxivity (8.5 mM⁻¹ s⁻¹ at 25 °C and 20 MHz) and a marked and selective relaxivity enhancement (37%) in the presence of Mg²⁺, opening interesting perspectives for the design of cation responsive contrast agents.

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Article information

DOI: https://doi.org/10.1039/C2CC30757J
Article type: Communication
Submitted: 02 Feb 2012
Accepted: 29 Feb 2012
First published: 29 Feb 2012

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Chem. Commun., 2012,48, 4085-4087

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Highly relaxing gadolinium based MRI contrast agents responsive to Mg²⁺ sensing

S. Abada, A. Lecointre, M. Elhabiri, D. Esteban-Gómez, C. Platas-Iglesias, G. Tallec, M. Mazzanti and L. J. Charbonnière, Chem. Commun., 2012, 48, 4085 DOI: 10.1039/C2CC30757J

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