Issue 42, 2012
From the journal:

Chemical Communications

Highly enantioselective asymmetric hydrogenation of (E)-β,β-disubstituted α,β-unsaturated Weinreb amides catalyzed by Ir(i) complexes of SpinPhox ligands†

Jian Shang,a   Zhaobin Han,a   Yang Li,a   Zheng Wanga  and  Kuiling Ding*a  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, P.R. China
E-mail: kding@mail.sioc.ac.cn
Fax: +86 21 64166128

Abstract

The Ir(I) complexes of chiral spiro phosphino–oxazoline ligands (SpinPhox) have demonstrated good to excellent enantioselectivity in the asymmetric hydrogenation (AH) of a variety of (E)-β,β-disubstituted α,β-unsaturated N-methoxy-N-methylamides, affording the corresponding optically active Weinreb amides with up to 97% ee.

Graphical abstract: Highly enantioselective asymmetric hydrogenation of (E)-β,β-disubstituted α,β-unsaturated Weinreb amides catalyzed by Ir(i) complexes of SpinPhox ligands

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Article information

DOI
https://doi.org/10.1039/C2CC30812F
Article type
Communication
Submitted
04 Feb 2012
Accepted
02 Apr 2012
First published
03 Apr 2012

Chem. Commun., 2012,48, 5172-5174

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Highly enantioselective asymmetric hydrogenation of (E)-β,β-disubstituted α,β-unsaturated Weinreb amides catalyzed by Ir(I) complexes of SpinPhox ligands

J. Shang, Z. Han, Y. Li, Z. Wang and K. Ding, Chem. Commun., 2012, 48, 5172 DOI: 10.1039/C2CC30812F

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