Issue 45, 2012

Hybridization-triggered isothermal signal amplification coupled with MutS for label-free and sensitive fluorescent assay of SNPs

Abstract

Combining the specific recognization of MutS protein for mismatched DNA sequences with the target-driven molecular switch that acts as both the template and primer of the polymerization reaction, a new label-free and sensitive fluorescent assay strategy for specific single-stranded DNA sequences or SNPs is proposed.

Graphical abstract: Hybridization-triggered isothermal signal amplification coupled with MutS for label-free and sensitive fluorescent assay of SNPs

Supplementary files

Article information

Article type
Communication
Submitted
08 Feb 2012
Accepted
16 Apr 2012
First published
17 Apr 2012

Chem. Commun., 2012,48, 5659-5661

Hybridization-triggered isothermal signal amplification coupled with MutS for label-free and sensitive fluorescent assay of SNPs

A. Jiao, J. Zheng, Y. Hu, G. Zhu, J. Li, H. Li, R. Yang and W. Tan, Chem. Commun., 2012, 48, 5659 DOI: 10.1039/C2CC30882G

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