Issue 32, 2012
From the journal:

Chemical Communications

Preparation of quinazolino[3,2-a]quinazolines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and amine†

Guanyinsheng Qiu,a   Yaohua He*b  and  Jie Wu*ac  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, China
E-mail: jie_wu@fudan.edu.cn
Fax: +86 21 6564 1740
Tel: +86 21 6510 2412

b Shanghai the 6th People's Hospital, Shanghai Jiaotong University, 600 Yishan Road, China

c Key Laboratory of Synthetic Organic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, China

Abstract

A palladium-catalyzed three-component reaction of bis-(2-iodoaryl)carbodiimide, isocyanide, and amine gives rise to quinazolino[3,2-a]quinazolines and related compounds in good yields. Multi-bonds are formed in one pot through nucleophilic attack, isocyanide insertion, and C–N coupling during the reaction process.

Graphical abstract: Preparation of quinazolino[3,2-a]quinazolines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and amine

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Article information

DOI
https://doi.org/10.1039/C2CC30928A
Article type
Communication
Submitted
09 Feb 2012
Accepted
27 Feb 2012
First published
28 Feb 2012

Chem. Commun., 2012,48, 3836-3838

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Preparation of quinazolino[3,2-a]quinazolines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and amine

G. Qiu, Y. He and J. Wu, Chem. Commun., 2012, 48, 3836 DOI: 10.1039/C2CC30928A

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