Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

Yujiro Hayashi; Yusuke Yasui; Masahiro Kojima; Tsuyoshi Kawamura; Hayato Ishikawa

doi:10.1039/C2CC31230A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile†‡

Yujiro Hayashi,*^a Yusuke Yasui,^a Masahiro Kojima,^a Tsuyoshi Kawamura^a and Hayato Ishikawa §^a

Author affiliations

* Corresponding authors

^a Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan
E-mail: hayashi@ci.kagu.tus.ac.jp
Fax: +81 (0)3-5261-4631
Tel: +81 (0)3-5228-8318

Abstract

The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.

This article is part of the themed collection: Organocatalysis

Download options Please wait...

Supplementary files

Supplementary information PDF (5969K)

Article information

DOI: https://doi.org/10.1039/C2CC31230A
Article type: Communication
Submitted: 18 Feb 2012
Accepted: 05 Mar 2012
First published: 30 Mar 2012

Download Citation

Chem. Commun., 2012,48, 4570-4572

Permissions

Request permissions

Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

Y. Hayashi, Y. Yasui, M. Kojima, T. Kawamura and H. Ishikawa, Chem. Commun., 2012, 48, 4570 DOI: 10.1039/C2CC31230A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile†‡

Abstract

Supplementary files

Article information

Download Citation

Permissions

Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

Social activity

Search articles by author

Spotlight

Advertisements