Issue 48, 2012
From the journal:

Chemical Communications

Redox-sensitive polymeric nanoparticles for drug delivery†

Hanjoung Cho,a   Jungeun Bae,a   Vivek K. Garripelli,a   Joel M. Anderson,b   Ho-Wook Junb  and  Seongbong Jo*a  

* Corresponding authors

a Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, USA
E-mail: seongjo@olemiss.edu
Fax: +1 662-915-1177
Tel: +1 662-915-5166

b Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, USA

Abstract

Bioresponsive polymeric nanoparticles have been extensively pursued for the development of tumor-targeted drug delivery. A novel redox-sensitive biodegradable polymer with “trimethyl-locked” benzoquinone was synthesized for the preparation of paclitaxel-incorporated nanoparticles. The synthesized redox-sensitive nanoparticles released paclitaxel in response to chemically triggered reduction.

Graphical abstract: Redox-sensitive polymeric nanoparticles for drug delivery

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Article information

DOI
https://doi.org/10.1039/C2CC31463K
Article type
Communication
Submitted
27 Feb 2012
Accepted
24 Apr 2012
First published
25 Apr 2012

Chem. Commun., 2012,48, 6043-6045

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Redox-sensitive polymeric nanoparticles for drug delivery

H. Cho, J. Bae, V. K. Garripelli, J. M. Anderson, H. Jun and S. Jo, Chem. Commun., 2012, 48, 6043 DOI: 10.1039/C2CC31463K

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