Issue 40, 2012
From the journal:

Chemical Communications

A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines†

P. Ricardo Girling,a   Andrei S. Batsanov,a   Hong C. Shenb  and  Andrew Whiting*a  

* Corresponding authors

a Centre for Sustainable Chemical Processes, Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: andy.whiting@durham.ac.uk
Fax: +44 191 384 4737
Tel: +44 191 334 2081

b Merck & Co., RY800-C114, 126 East Lincoln Avenue, P.O. Box 2000, Rahway, USA

Abstract

Reaction of methoxyvinylmethylketone with different amines and aldehydes under Lewis-acid catalysed conditions results in a novel, formal, step-wise [1+2+1+2]-cycloaddition to give dihydropyridine products.

Graphical abstract: A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines

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Article information

DOI
https://doi.org/10.1039/C2CC31495A
Article type
Communication
Submitted
28 Feb 2012
Accepted
15 Mar 2012
First published
15 Mar 2012

Chem. Commun., 2012,48, 4893-4895

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A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines

P. R. Girling, A. S. Batsanov, H. C. Shen and A. Whiting, Chem. Commun., 2012, 48, 4893 DOI: 10.1039/C2CC31495A

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