Issue 45, 2012

Envisioning an enzymatic Diels–Alder reaction by in situ acid–base catalyzed diene generation

Abstract

We present and evaluate a new and potentially efficient route for enzyme-mediated Diels–Alder reactions, utilizing general acid–base catalysis. The viability of employing the active site of ketosteroid isomerase is demonstrated.

Graphical abstract: Envisioning an enzymatic Diels–Alder reaction by in situ acid–base catalyzed diene generation

Supplementary files

Article information

Article type
Communication
Submitted
28 Feb 2012
Accepted
30 Mar 2012
First published
30 Mar 2012

Chem. Commun., 2012,48, 5665-5667

Envisioning an enzymatic Diels–Alder reaction by in situ acid–base catalyzed diene generation

M. Linder, A. J. Johansson, B. Manta, P. Olsson and T. Brinck, Chem. Commun., 2012, 48, 5665 DOI: 10.1039/C2CC31502E

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