Issue 44, 2012
From the journal:

Chemical Communications

Trichlorosilyl triflate-mediated enantioselective directed cross-aldol reaction between ketones using a chiral phosphine oxide as an organocatalyst†‡

Shohei Aoki,a   Shunsuke Kotani,*b   Masaharu Sugiuraa  and  Makoto Nakajima*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, Japan
E-mail: nakajima@gpo.kumamoto-u.ac.jp
Fax: +81-963627692

b Priority Organization for Innovation and Excellence, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, Japan
E-mail: skotani@gpo.kumamoto-u.ac.jp

Abstract

Trichlorosilyl triflate-promoted directed cross-aldol reaction between ketones in the presence of a chiral phosphine oxide as an organocatalyst is described. This is the first enantioselective cross-aldol reaction between simple ketones with good enantioselectivity.

Graphical abstract: Trichlorosilyl triflate-mediated enantioselective directed cross-aldol reaction between ketones using a chiral phosphine oxide as an organocatalyst

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Article information

DOI
https://doi.org/10.1039/C2CC31543B
Article type
Communication
Submitted
29 Feb 2012
Accepted
10 Apr 2012
First published
27 Apr 2012

Chem. Commun., 2012,48, 5524-5526

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Trichlorosilyl triflate-mediated enantioselective directed cross-aldol reaction between ketones using a chiral phosphine oxide as an organocatalyst

S. Aoki, S. Kotani, M. Sugiura and M. Nakajima, Chem. Commun., 2012, 48, 5524 DOI: 10.1039/C2CC31543B

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