Issue 45, 2012

An efficient synthetic approach to 6,5′-(S)- and 6,5′-(R)-cyclouridine

Abstract

Here we present new routes for the efficient syntheses of 6,5′-(S)- and 6,5′-(R)-cyclouridine. The syntheses utilize readily accessible uridine as a starting material. This route to the R diastereomer is significantly more efficient than previous synthetic efforts, allowing us to obtain large amounts of pure material for future biological testing.

Graphical abstract: An efficient synthetic approach to 6,5′-(S)- and 6,5′-(R)-cyclouridine

Supplementary files

Article information

Article type
Communication
Submitted
02 Mar 2012
Accepted
03 Apr 2012
First published
10 Apr 2012

Chem. Commun., 2012,48, 5587-5589

An efficient synthetic approach to 6,5′-(S)- and 6,5′-(R)-cyclouridine

C. S. Theile and L. W. McLaughlin, Chem. Commun., 2012, 48, 5587 DOI: 10.1039/C2CC31597A

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