Issue 50, 2012
From the journal:

Chemical Communications

Synthesis of adenosine functionalized metal immobilized magnetic nanoparticles for highly selective and sensitive enrichment of phosphopeptides†

Liyuan Zhang,ab   Qun Zhao,ab   Zhen Liang,a   Kaiguang Yang,a   Liangliang Sun,ab   Lihua Zhang*a  and  Yukui Zhanga  

* Corresponding authors

a National Chromatographic R. & A. Center, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Dalian 116023, China
E-mail: lihuazhang@dicp.ac.cn
Fax: +86-411-84379560

b Graduate School of Chinese Academy of Sciences, Beijing 100039, China

Abstract

A new type of IMAC material, with ATP as the chelating ligand, was synthesized and applied to capture phosphopeptides. For the first time, the approach for phosphopeptide enrichment could provide selectivity under 5000-fold dilution by nonphosphopeptides, and sensitivity of on-target enrichment at 3 amol.

Graphical abstract: Synthesis of adenosine functionalized metal immobilized magnetic nanoparticles for highly selective and sensitive enrichment of phosphopeptides

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Article information

DOI
https://doi.org/10.1039/C2CC31641B
Article type
Communication
Submitted
05 Mar 2012
Accepted
01 May 2012
First published
01 May 2012

Chem. Commun., 2012,48, 6274-6276

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Synthesis of adenosine functionalized metal immobilized magnetic nanoparticles for highly selective and sensitive enrichment of phosphopeptides

L. Zhang, Q. Zhao, Z. Liang, K. Yang, L. Sun, L. Zhang and Y. Zhang, Chem. Commun., 2012, 48, 6274 DOI: 10.1039/C2CC31641B

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