Issue 45, 2012

Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties

Abstract

We report the synthesis and biophysical characterization of a novel class of zwitterionic lipids (ZL) with head groups containing a 3° or 4° amine and carboxylate. ZL form stable liposomes that exhibit head group dependent, pH-responsive biophysical characteristics. These lipids may be suitable components for drug delivery applications due to their ease of synthesis and unique pH-dependent properties.

Graphical abstract: Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties

Supplementary files

Article information

Article type
Communication
Submitted
07 Mar 2012
Accepted
10 Apr 2012
First published
11 Apr 2012

Chem. Commun., 2012,48, 5575-5577

Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties

C. L. Walsh, J. Nguyen and F. C. Szoka, Chem. Commun., 2012, 48, 5575 DOI: 10.1039/C2CC31710A

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