Issue 49, 2012
From the journal:

Chemical Communications

Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA†

Xiaofeng Wei,a   Wenlie Lin,b   Na Ma,a   Fang Luo,a   Zhenyu Lin,*a   Longhua Guo,a   Bin Qiua  and  Guonan Chen*a  

* Corresponding authors

a Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety (Fuzhou University), Fujian Province Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, China
E-mail: zylin@fzu.edu.cn, gnchen@fzu.edu.cn
Fax: (+86)-591-22866135

b Yanchang Oil field Corp. Ltd., Shanxi, China

Abstract

Based on the specific folic acid–folate receptor (FA–FR) interaction, macromolecular FR can bind with FA-linked DNA–small molecule chimeras, which can prevent enzymolysis by exonuclease III (Exo III), enabling a novel fluorescence biosensor for FR to be developed using quinaldine red as a G-quadruplex-binding probe.

Graphical abstract: Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA

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Article information

DOI
https://doi.org/10.1039/C2CC31979A
Article type
Communication
Submitted
28 Jan 2012
Accepted
30 Apr 2012
First published
30 Apr 2012

Chem. Commun., 2012,48, 6184-6186

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Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA

X. Wei, W. Lin, N. Ma, F. Luo, Z. Lin, L. Guo, B. Qiu and G. Chen, Chem. Commun., 2012, 48, 6184 DOI: 10.1039/C2CC31979A

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