Issue 66, 2012
From the journal:

Chemical Communications

Conformations of individual quadruplex units studied in the context of extended human telomeric DNA†

Vijay Singh,‡a   Mykhailo Azarkh,a   Malte Drescher*a  and  Jörg S. Hartig*a  

* Corresponding authors

a Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, 78457 Konstanz, Germany
E-mail: joerg.hartig@uni-konstanz.de, malte.drescher@uni-konstanz.de

Abstract

G-quadruplex conformations within a sequence of three quadruplex units of human telomeric DNA were studied by two-frequency pulsed electron paramagnetic resonance (EPR) spectroscopy. In contrast to some individual G-quadruplexes, within the higher-order human telomeric sequence a (3+1) hybrid structure is formed.

Graphical abstract: Conformations of individual quadruplex units studied in the context of extended human telomeric DNA

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Article information

DOI
https://doi.org/10.1039/C2CC32012F
Article type
Communication
Submitted
19 Mar 2012
Accepted
10 Apr 2012
First published
10 Apr 2012

Chem. Commun., 2012,48, 8258-8260

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Conformations of individual quadruplex units studied in the context of extended human telomeric DNA

V. Singh, M. Azarkh, M. Drescher and J. S. Hartig, Chem. Commun., 2012, 48, 8258 DOI: 10.1039/C2CC32012F

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