Issue 76, 2012

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Abstract

A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.

Graphical abstract: A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Supplementary files

Article information

Article type
Communication
Submitted
28 Mar 2012
Accepted
31 May 2012
First published
07 Jun 2012

Chem. Commun., 2012,48, 9462-9464

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

H. He, D. S. Chan, C. Leung and D. Ma, Chem. Commun., 2012, 48, 9462 DOI: 10.1039/C2CC32253F

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