Formal asymmetric enone aminohydroxylation: organocatalytic one-pot synthesis of 4,5-disubstituted oxazolidinones

Abstract

A formal asymmetric organocatalytic aminohydroxylation reaction of enones has been achieved via an aziridination–double S_N2 sequence. As a part of the reaction design, the generated amino alcohol products are isolated as the corresponding oxazolidinones in good yields and excellent stereoselectivities.