Issue 53, 2012
From the journal:

Chemical Communications

Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides†

Joseph I. Ambrus,a   Jill I. Halliday,a   Nicholas Kanizaj,a   Nathan Absalom,b   Kasper Harpsøe,c   Thomas Balle,d   Mary Chebibb  and  Malcolm D. McLeod*a  

* Corresponding authors

a Research School of Chemistry, Australian National University, Canberra, Australia
E-mail: malcolm.mcleod@anu.edu.au

b Faculty of Pharmacy, The University of Sydney, Sydney, Australia

c NNF Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark

d Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

Abstract

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

Graphical abstract: Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

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Article information

DOI
https://doi.org/10.1039/C2CC32442C
Article type
Communication
Submitted
05 Apr 2012
Accepted
09 May 2012
First published
10 May 2012

Chem. Commun., 2012,48, 6699-6701

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Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

J. I. Ambrus, J. I. Halliday, N. Kanizaj, N. Absalom, K. Harpsøe, T. Balle, M. Chebib and M. D. McLeod, Chem. Commun., 2012, 48, 6699 DOI: 10.1039/C2CC32442C

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