Issue 52, 2012

Regio- and stereoselective syntheses of piperidine derivatives via ruthenium-catalyzed coupling of propargylic amides and allylic alcohols

Abstract

Intermolecular selective coupling of linear allylic alcohols and propargylic amides occurs in the presence of a catalytic amount of the cationic ruthenium complex [Cp*Ru(NCCH3)3]PF6 followed by condensation to generate six-membered cyclic enamides or hemiaminal ethers with water as the only side product.

Graphical abstract: Regio- and stereoselective syntheses of piperidine derivatives via ruthenium-catalyzed coupling of propargylic amides and allylic alcohols

Supplementary files

Article information

Article type
Communication
Submitted
06 Apr 2012
Accepted
08 May 2012
First published
24 May 2012

Chem. Commun., 2012,48, 6589-6591

Regio- and stereoselective syntheses of piperidine derivatives via ruthenium-catalyzed coupling of propargylic amides and allylic alcohols

S. Murugesan, F. Jiang, M. Achard, C. Bruneau and S. Dérien, Chem. Commun., 2012, 48, 6589 DOI: 10.1039/C2CC32497K

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