Issue 58, 2012
From the journal:

Chemical Communications

Exploring the effect of sialic acid orientation on ligand–receptor interactions†

Rohan Yadava  and  Raghavendra Kikkeri*a  

* Corresponding authors

a Indian Institute of Science Education and Research, Sai Trinity Building, Pune 411021, Pashan, India
E-mail: rkikkeri@iiserpune.ac.in
Fax: +91-20-25899790
Tel: +91-20-25908207

Abstract

Here, we present the synthesis of two sialo-micelles to validate the significance of sialic acid orientation during specific carbohydrate–protein and carbohydrate–carbohydrate interactions. Our data clearly suggest that orientation of carboxylic acid and glycerol side chains of sialic acid moieties exert fine tuning of ligand–receptor interactions.

Graphical abstract: Exploring the effect of sialic acid orientation on ligand–receptor interactions

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Article information

DOI
https://doi.org/10.1039/C2CC32587J
Article type
Communication
Submitted
11 Apr 2012
Accepted
16 May 2012
First published
16 May 2012

Chem. Commun., 2012,48, 7265-7267

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Exploring the effect of sialic acid orientation on ligand–receptor interactions

R. Yadav and R. Kikkeri, Chem. Commun., 2012, 48, 7265 DOI: 10.1039/C2CC32587J

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