Issue 51, 2012
From the journal:

Chemical Communications

Femtomolar detection of a cancer biomarkerprotein in serum with ultralow background current by anodic stripping voltammetry†

Muhammad J. A. Shiddiky,‡*ab   Prakash H. Kithva,‡ab   Sakandar Raufa  and  Matt Trau*abc  

* Corresponding authors

a Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD 4072, Australia

b Centre for Biomarker Research and Development, University of Queensland, Brisbane, QLD 4072, Australia
E-mail: m.shiddiky@uq.edu.au, m.trau@uq.edu.au
Fax: +61-33463973
Tel: +61-33464178

c School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia

Abstract

An electrochemical immunosensor for the detection of a cancer biomarker protein in serum at femtomolar concentrations with ultralow background response has been developed, which consists of (i) a hydrophilic polyacrylic acid brush-modified indium tin oxide substrate as an antifouling substrate and (ii) a graphene–quantum dots–antibody ‘bionanoconjugate’ as a signal amplification label in voltammetric detection of targets in a glassy carbon electrode.

Graphical abstract: Femtomolar detection of a cancer biomarker protein in serum with ultralow background current by anodic stripping voltammetry

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Article information

DOI
https://doi.org/10.1039/C2CC32810K
Article type
Communication
Submitted
02 Mar 2012
Accepted
01 May 2012
First published
01 May 2012

Chem. Commun., 2012,48, 6411-6413

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Femtomolar detection of a cancer biomarker protein in serum with ultralow background current by anodic stripping voltammetry

M. J. A. Shiddiky, P. H. Kithva, S. Rauf and M. Trau, Chem. Commun., 2012, 48, 6411 DOI: 10.1039/C2CC32810K

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