Issue 57, 2012

Gold-catalyzed synthesis of substituted 2-aminofurans via formal [4+1]-cycloadditions on 3-en-1-ynamides

Abstract

Gold-catalyzed formal [4+1]-cycloadditions between 3-en-1-ynamides 1 and 8-methylquinoline oxide are reported. The success of this reaction relies on a hypothetic oxa-Nazarov cyclization on gold-stabilized allylic cations. Preliminary results on a new 1,2-difunctionalization of 3-en-1-ynamide are also reported.

Graphical abstract: Gold-catalyzed synthesis of substituted 2-aminofurans via formal [4+1]-cycloadditions on 3-en-1-ynamides

Supplementary files

Article information

Article type
Communication
Submitted
27 Apr 2012
Accepted
18 May 2012
First published
18 May 2012

Chem. Commun., 2012,48, 7200-7202

Gold-catalyzed synthesis of substituted 2-aminofurans via formal [4+1]-cycloadditions on 3-en-1-ynamides

R. B. Dateer, K. Pati and R. Liu, Chem. Commun., 2012, 48, 7200 DOI: 10.1039/C2CC33030J

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