Issue 61, 2012
From the journal:

Chemical Communications

A photochromic ATP analogue driving a motor protein with reversible light-controlled motility: controlling velocity and binding manner of a kinesin–microtubule system in an in vitro motility assay†

Takashi Kamei,a   Tuyoshi Fukaminatoa  and  Nobuyuki Tamaoki*a  

* Corresponding authors

a Research Institute for Electronic Science, Hokkaido University, N20, W10, Kita-ku, Sapporo, Hokkaido, Japan
E-mail: tamaoki@es.hokudai.ac.jp
Fax: +81-11-706-9357
Tel: +81-11-706-9356

Abstract

We synthesized two photochromic ATP analogues (ATP-Azos) featuring azobenzene derivatives tethered at the 2′ position of the ribose ring. In the presence of the ATP-Azo tethering p-tert-butylazobenzene, we observed reversible photo-control of the motility, velocity and binding manner, of a kinesin–microtubule system in an in vitro motility assay.

Graphical abstract: A photochromic ATP analogue driving a motor protein with reversible light-controlled motility: controlling velocity and binding manner of a kinesin–microtubule system in an in vitro motility assay

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Article information

DOI
https://doi.org/10.1039/C2CC33552B
Article type
Communication
Submitted
13 Mar 2012
Accepted
07 Jun 2012
First published
13 Jun 2012

Chem. Commun., 2012,48, 7625-7627

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A photochromic ATP analogue driving a motor protein with reversible light-controlled motility: controlling velocity and binding manner of a kinesin–microtubule system in an in vitro motility assay

T. Kamei, T. Fukaminato and N. Tamaoki, Chem. Commun., 2012, 48, 7625 DOI: 10.1039/C2CC33552B

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