Issue 71, 2012
From the journal:

Chemical Communications

Ru-catalyzed hydrogenation of 3,5-diketo amides: simultaneous control of chemo- and enantioselectivity†

Wanfang Li,a   Weizheng Fan,a   Xin Ma,a   Xiaoming Tao,a   Xiaoming Li,a   Xiaomin Xiea  and  Zhaoguo Zhang*ab  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
E-mail: zhaoguo@sjtu.edu.cn

b State Key laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China

Abstract

By modulating the chelating priorities of the different directing groups in 3,5-diketo amides with the assistance from coordinating solvent, highly chemo- and enantioselective hydrogenation of the C3-carbonyls was achieved in the presence of [RuCl(benzene)(S)-SunPhos]Cl in THF.

Graphical abstract: Ru-catalyzed hydrogenation of 3,5-diketo amides: simultaneous control of chemo- and enantioselectivity

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Article information

DOI
https://doi.org/10.1039/C2CC33695B
Article type
Communication
Submitted
23 May 2012
Accepted
17 Jul 2012
First published
18 Jul 2012

Chem. Commun., 2012,48, 8976-8978

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Ru-catalyzed hydrogenation of 3,5-diketo amides: simultaneous control of chemo- and enantioselectivity

W. Li, W. Fan, X. Ma, X. Tao, X. Li, X. Xie and Z. Zhang, Chem. Commun., 2012, 48, 8976 DOI: 10.1039/C2CC33695B

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