Issue 68, 2012
From the journal:

Chemical Communications

Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs†

Vladimir B. Arion,*a   Anatolie Dobrov,a   Simone Göschl,a   Michael A. Jakupec,a   Bernhard K. Kepplera  and  Peter Raptab  

* Corresponding authors

a Institute of Inorganic Chemistry of the University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria
E-mail: vladimir.arion@univie.ac.at

b Department of Physical Chemistry, Slovak University of Technology, Radlinského 9, SK-81237 Bratislava, Slovak Republic

Abstract

A modified paullone ligand bearing a TEMPO free-radical unit (HL) and its ruthenium(II) and osmium(II)-arene complexes [M(p-cymene)(HL)Cl]Cl·nH2O (M = Ru, Os) exhibit high antiproliferative activity in human cancer cell lines.

Graphical abstract: Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs

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Article information

DOI
https://doi.org/10.1039/C2CC33786J
Article type
Communication
Submitted
26 May 2012
Accepted
02 Jul 2012
First published
02 Jul 2012

Chem. Commun., 2012,48, 8559-8561

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Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs

V. B. Arion, A. Dobrov, S. Göschl, M. A. Jakupec, B. K. Keppler and P. Rapta, Chem. Commun., 2012, 48, 8559 DOI: 10.1039/C2CC33786J

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