Issue 60, 2012

Sequence-specific inhibition of a designed metallopeptide catalyst

Abstract

Rhodium metallopeptides catalyze proximity-driven modification of peptide and protein substrates with enzyme-like selectivity. In this communication, we demonstrate that designed metallopeptide catalysts can be inhibited in a sequence-specific manner, mimicking the inhibition and regulation of natural enzymes. We demonstrate sub-micromolar inhibition by a histidine-containing inhibitor peptide, taking advantage of cooperative supramolecular assembly and inorganic coordination.

Graphical abstract: Sequence-specific inhibition of a designed metallopeptide catalyst

Supplementary files

Article information

Article type
Communication
Submitted
04 May 2012
Accepted
09 Jun 2012
First published
13 Jun 2012

Chem. Commun., 2012,48, 7492-7494

Sequence-specific inhibition of a designed metallopeptide catalyst

B. V. Popp, Z. Chen and Z. T. Ball, Chem. Commun., 2012, 48, 7492 DOI: 10.1039/C2CC33808D

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